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Effects of nucleic acid local structure and magnesium ions on minus-strand transfer mediated by the nucleic acid chaperone activity of HIV-1 nucleocapsid protein

HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which is required for highly specific and efficient reverse transcription. Here, we demonstrate that local structure of acceptor RNA at a potential nucleation site, rather than overall thermodynamic stability, is a critical determinant for...

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Detalhes bibliográficos
Main Authors: Wu, Tiyun, Heilman-Miller, Susan L., Levin, Judith G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1919501/
https://ncbi.nlm.nih.gov/pubmed/17553835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm375
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