Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein

During minus-strand DNA synthesis, RNase H degrades viral RNA sequences, generating potential plus-strand DNA primers. However, selection of the 3′ polypurine tract (PPT) as the exclusive primer is required for formation of viral DNA with the correct 5′-end and for subsequent integration. Here we sh...

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Bibliografiske detaljer
Main Authors: Post, Klara, Kankia, Besik, Gopalakrishnan, Swathi, Yang, Victoria, Cramer, Elizabeth, Saladores, Pilar, Gorelick, Robert J., Guo, Jianhui, Musier-Forsyth, Karin, Levin, Judith G.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665208/
https://ncbi.nlm.nih.gov/pubmed/19158189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1045
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