ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke

BACKGROUND: In response to DNA damage or structural alterations of chromatin, histone H2AX may be phosphorylated on Ser139 by phosphoinositide 3-kinase related protein kinases (PIKKs) such as ataxia telangiectasia mutated (ATM), ATM-and Rad-3 related (ATR) kinase, or by DNA dependent protein kinase...

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Main Authors: Tanaka, Toshiki, Huang, Xuan, Jorgensen, Ellen, Gietl, Diana, Traganos, Frank, Darzynkiewicz, Zbigniew, Albino, Anthony P
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1919366/
https://ncbi.nlm.nih.gov/pubmed/17594478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-8-26
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