The shiverer mutation affects the persistence of Theiler's virus in the central nervous system.

Theiler's virus persists in the white matter of the spinal cord of genetically susceptible mice and causes primary demyelination. The virus persists in macrophages/microglial cells, but also in oligodendrocytes, the myelin-forming cells. Susceptibility/resistance to this chronic infection has b...

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Bibliographic Details
Main Authors: Bihl, F, Pena-Rossi, C, Guénet, J L, Brahic, M, Bureau, J F
Format: Artigo
Language:Inglês
Published: 1997
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC191735/
https://ncbi.nlm.nih.gov/pubmed/9188567
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