Identification of the human immunodeficiency virus reverse transcriptase residues that contribute to the activity of diverse nonnucleoside inhibitors.

The reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) is potently inhibited by a structurally diverse group of nonnucleoside compounds. These include pyridinone derivatives, tetrahydroimadazo[4,5,1-j,k][1,4]-benzodiazepin-2(1H)-one and -thione, and BI-RG-587 (nevirapine). The...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Condra, J H, Emini, E A, Gotlib, L, Graham, D J, Schlabach, A J, Wolfgang, J A, Colonno, R J, Sardana, V V
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1992
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191601/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1380789/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.7.1441
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