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Identification of a silencing element in the human 15q11-q13 imprinting center by using transgenic Drosophila

Prader–Willi syndrome (PWS) and Angelman syndrome are neurogenetic disorders caused by the lack of a paternal or a maternal contribution from human chromosome 15q11-q13, respectively. Deletions in the transcription unit of the imprinted SNRPN gene have been found in patients who have PWS or Angelman...

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Hlavní autoři: Lyko, Frank, Buiting, Karin, Horsthemke, Bernhard, Paro, Renato
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1998
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC19156/
https://ncbi.nlm.nih.gov/pubmed/9465079
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