Identification of a silencing element in the human 15q11-q13 imprinting center by using transgenic Drosophila

Prader–Willi syndrome (PWS) and Angelman syndrome are neurogenetic disorders caused by the lack of a paternal or a maternal contribution from human chromosome 15q11-q13, respectively. Deletions in the transcription unit of the imprinted SNRPN gene have been found in patients who have PWS or Angelman...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Lyko, Frank, Buiting, Karin, Horsthemke, Bernhard, Paro, Renato
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1998
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19156/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9465079/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.4.1698
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