Age and origin of two common MLH1 mutations predisposing to hereditary colon cancer.

Two mutations in the DNA mismatch repair gene MLH1, referred to as mutations 1 and 2, are frequent among Finnish kindreds with hereditary nonpolyposis colorectal cancer (HNPCC). In order to assess the ages and origins of these mutations, we constructed a map of 15 microsatellite markers around MLH1...

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Main Authors: Moisio, A. L., Sistonen, P., Weissenbach, J., de la Chapelle, A., Peltomäki, P.
Format: Artigo
Jezik:Inglês
Izdano: 1996
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1914865/
https://ncbi.nlm.nih.gov/pubmed/8940269
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