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Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.

The autosomal recessive trait of thiopurine S-methytransferase (TPMT) deficiency is associated with severe hematopoietic toxicity when patients are treated with standard doses of mercaptopurine, azathioprine, or thioguanine. To define the molecular mechanism of this genetic polymorphism, we cloned a...

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Библиографические подробности
Главные авторы: Tai, H. L., Krynetski, E. Y., Yates, C. R., Loennechen, T., Fessing, M. Y., Krynetskaia, N. F., Evans, W. E.
Формат: Artigo
Язык:Inglês
Опубликовано: 1996
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1914689/
https://ncbi.nlm.nih.gov/pubmed/8644731
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