Nomenclature for alleles of the thiopurine methyltransferase gene

The drug-metabolizing enzyme thiopurine methyltransferase (TPMT) has become one of the best examples of pharmacogenomics to be translated into routine clinical practice. TPMT metabolizes the thiopurines 6-mercaptopurine, 6-thioguanine, and azathioprine, drugs that are widely used for treatment of ac...

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Main Authors: Appell, Malin L., Berg, Jonathan, Duley, John, Evans, William E., Kennedy, Martin A., Lennard, Lynne, Marinaki, Tony, McLeod, Howard L., Relling, Mary V., Schaeffeler, Elke, Schwab, Matthias, Weinshilboum, Richard, Yeoh, Allen E.J., McDonagh, Ellen M., Hebert, Joan M., Klein, Teri E., Coulthard, Sally A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727893/
https://ncbi.nlm.nih.gov/pubmed/23407052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32835f1cc0
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