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Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization.

The ability of mucosally delivered plasmid DNA encoding glycoprotein B (gB) of herpes simplex virus type 1 (HSV-1) to generate systemic as well as distal mucosal immunity was evaluated. BALB/c mice were immunized intranasally (i.n.) with gB DNA or DNA expressing beta-galactosidase (beta-Gal). Two da...

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Détails bibliographiques
Auteurs principaux: Kuklin, N, Daheshia, M, Karem, K, Manickan, E, Rouse, B T
Format: Artigo
Langue:Inglês
Publié: 1997
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC191446/
https://ncbi.nlm.nih.gov/pubmed/9060677
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