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Acute Ethanol Pretreatment Increases FAS-Mediated Liver Injury in Mice: Role of Oxidative Stress and CYP2E1-Dependent and Independent Pathways
This study evaluated whether acute ethanol pretreatment potentiates Fas-mediated liver injury and if oxidative stress and CYP2E1 play a role in any enhanced hepatotoxicity. There were 3-fold increases of transaminases and more extensive apoptotic necrosis of hepatocytes, and focal hemorrhages of the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1914038/ https://ncbi.nlm.nih.gov/pubmed/17349925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2006.12.023 |
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