Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice

We used gene knockout mice to explore the role of Angiopoietin-like-4 (Angptl4) in lipid metabolism as well as to generate anti-Angptl4 mAbs with pharmacological activity. Angptl4 −/− mice had lower triglyceride (TG) levels resulting both from increased very low-density lipoprotein (VLDL) clearance...

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Detalhes bibliográficos
Main Authors: Desai, Urvi, Lee, E-Chiang, Chung, Kyu, Gao, Cuihua, Gay, Jason, Key, Billie, Hansen, Gwenn, Machajewski, Dennis, Platt, Kenneth A., Sands, Arthur T., Schneider, Matthias, Van Sligtenhorst, Isaac, Suwanichkul, Adisak, Vogel, Peter, Wilganowski, Nat, Wingert, June, Zambrowicz, Brian P., Landes, Greg, Powell, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913890/
https://ncbi.nlm.nih.gov/pubmed/17609370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705041104
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