Formaldehyde at Low Concentration Induces Protein Tau into Globular Amyloid-Like Aggregates In Vitro and In Vivo

Recent studies have shown that neurodegeneration is closely related to misfolding and aggregation of neuronal tau. Our previous results show that neuronal tau aggregates in formaldehyde solution and that aggregated tau induces apoptosis of SH-SY5Y and hippocampal cells. In the present study, based o...

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Detalhes bibliográficos
Main Authors: Nie, Chun Lai, Wei, Yan, Chen, Xinyong, Liu, Yan Ying, Dui, Wen, Liu, Ying, Davies, Martyn C., Tendler, Saul J.B., He, Rong Giao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913207/
https://ncbi.nlm.nih.gov/pubmed/17637844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000629
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