Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells.

The vaccinia virus E3L gene codes for double-stranded RNA (dsRNA) binding proteins which can prevent activation of the dsRNA-dependent, interferon-induced protein kinase PKR. Activated PKR has been shown to induce apoptosis in HeLa cells. HeLa cells infected with vaccinia virus with the E3L gene del...

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Publié dans:	J Virol
Auteurs principaux:	Kibler, K V, Shors, T, Perkins, K B, Zeman, C C, Banaszak, M P, Biesterfeldt, J, Langland, J O, Jacobs, B L
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1997
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191284/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032331/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.3.1992-2003.1997
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