Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells.

The vaccinia virus E3L gene codes for double-stranded RNA (dsRNA) binding proteins which can prevent activation of the dsRNA-dependent, interferon-induced protein kinase PKR. Activated PKR has been shown to induce apoptosis in HeLa cells. HeLa cells infected with vaccinia virus with the E3L gene del...

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Detalhes bibliográficos
Main Authors: Kibler, K V, Shors, T, Perkins, K B, Zeman, C C, Banaszak, M P, Biesterfeldt, J, Langland, J O, Jacobs, B L
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC191284/
https://ncbi.nlm.nih.gov/pubmed/9032331
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