Intergenic Transcription, Cell-Cycle and the Developmentally Regulated Epigenetic Profile of the Human Beta-Globin Locus

Several lines of evidence have established strong links between transcriptional activity and specific post-translation modifications of histones. Here we show using RNA FISH that in erythroid cells, intergenic transcription in the human β-globin locus occurs over a region of greater than 250 kb incl...

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Detalhes bibliográficos
Main Authors: Miles, Joanne, Mitchell, Jennifer A., Chakalova, Lyubomira, Goyenechea, Beatriz, Osborne, Cameron S., O'Neill, Laura, Tanimoto, Keiji, Engel, James Douglas, Fraser, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1910613/
https://ncbi.nlm.nih.gov/pubmed/17637845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000630
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