Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.

Several lines of evidence have established strong links between transcriptional activity and specific post-translation modifications of histones. Here we show using RNA FISH that in erythroid cells, intergenic transcription in the human beta-globin locus occurs over a region of greater than 250 kb i...

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Principais autores:	Joanne Miles, Jennifer A Mitchell, Lyubomira Chakalova, Beatriz Goyenechea, Cameron S Osborne, Laura O'Neill, Keiji Tanimoto, James Douglas Engel, Peter Fraser
格式:	Artigo
語言:	Inglês
出版:	Public Library of Science (PLoS) 2007-07-01
叢編:	PLoS ONE
在線閱讀:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000630&type=printable
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