The HNF1/HNF4-dependent We2 element of woodchuck hepatitis virus controls viral replication and can activate the N-myc2 promoter.

Transcriptional activation of myc family proto-oncogenes through the insertion of viral sequences is the predominant mechanism by which woodchuck hepatitis virus (WHV) induces liver tumors in chronically infected animals. The main target is N-myc2, a functional retroposon of the N-myc gene, but c-my...

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Hlavní autoři: Fourel, G, Ringeisen, F, Flajolet, M, Tronche, F, Pontoglio, M, Tiollais, P, Buendia, M A
Médium: Artigo
Jazyk:Inglês
Vydáno: 1996
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC190950/
https://ncbi.nlm.nih.gov/pubmed/8970982
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