The HNF1/HNF4-dependent We2 element of woodchuck hepatitis virus controls viral replication and can activate the N-myc2 promoter.

Transcriptional activation of myc family proto-oncogenes through the insertion of viral sequences is the predominant mechanism by which woodchuck hepatitis virus (WHV) induces liver tumors in chronically infected animals. The main target is N-myc2, a functional retroposon of the N-myc gene, but c-my...

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Bibliographic Details

Published in:	J Virol
Main Authors:	Fourel, G, Ringeisen, F, Flajolet, M, Tronche, F, Pontoglio, M, Tiollais, P, Buendia, M A
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1996
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190950/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8970982/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.12.8571-8583.1996
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