Molecular characterization of replication-competent variants of adenovirus vectors and genome modifications to prevent their occurrence.

Adenovirus (Ad) vectors for gene therapy are made replication defective by deletion of E1 region genes. For isolation, propagation, and large-scale production of such vectors, E1 functions are supplied in trans from a stable cell line. Virtually all Ad vectors used for clinical studies are produced...

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ग्रंथसूची विवरण

में प्रकाशित:	J Virol
मुख्य लेखकों:	Hehir, K M, Armentano, D, Cardoza, L M, Choquette, T L, Berthelette, P B, White, G A, Couture, L A, Everton, M B, Keegan, J, Martin, J M, Pratt, D A, Smith, M P, Smith, A E, Wadsworth, S C
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	American Society for Microbiology (ASM) 1996
विषय:	Research Article
ऑनलाइन पहुंच:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190936/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8970968/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.12.8459-8467.1996
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