Molecular characterization of replication-competent variants of adenovirus vectors and genome modifications to prevent their occurrence.
Adenovirus (Ad) vectors for gene therapy are made replication defective by deletion of E1 region genes. For isolation, propagation, and large-scale production of such vectors, E1 functions are supplied in trans from a stable cell line. Virtually all Ad vectors used for clinical studies are produced...
محفوظ في:
| الحاوية / القاعدة: | J Virol |
|---|---|
| المؤلفون الرئيسيون: | , , , , , , , , , , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
American Society for Microbiology (ASM)
1996
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190936/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8970968/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.12.8459-8467.1996 |
| الوسوم: |
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