Molecular characterization of replication-competent variants of adenovirus vectors and genome modifications to prevent their occurrence.

Adenovirus (Ad) vectors for gene therapy are made replication defective by deletion of E1 region genes. For isolation, propagation, and large-scale production of such vectors, E1 functions are supplied in trans from a stable cell line. Virtually all Ad vectors used for clinical studies are produced...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Hehir, K M, Armentano, D, Cardoza, L M, Choquette, T L, Berthelette, P B, White, G A, Couture, L A, Everton, M B, Keegan, J, Martin, J M, Pratt, D A, Smith, M P, Smith, A E, Wadsworth, S C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190936/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8970968/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.12.8459-8467.1996
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