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The design and characterization of two proteins with 88% sequence identity but different structure and function
To identify a simplified code for conformational switching, we have redesigned two natural proteins to have 88% sequence identity but different tertiary structures: a 3-α helix fold and an α/β fold. We describe the design of these homologous heteromorphic proteins, their structural properties as det...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1906725/ https://ncbi.nlm.nih.gov/pubmed/17609385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700922104 |
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