Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues.

First-generation adenovirus vectors will have limited application in gene therapy for chronic diseases because of destructive host immune responses. Important immune effectors include CD8+ T cells, which mediate target cell destruction and ablate transgene expression, and B cells, which produce neut...

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Bibliographic Details
Main Authors: Yang, Y, Su, Q, Grewal, I S, Schilz, R, Flavell, R A, Wilson, J M
Format: Artigo
Language:Inglês
Published: 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC190663/
https://ncbi.nlm.nih.gov/pubmed/8709265
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