Induction of IL-15 by TCR/CD3 aggregation depends on IFN-γ and protects against apoptosis of immature thymocytes in vivo

TCR/CD3 aggregation by injection of anti-CD3 Ab produces T cell activation, release of cytokines such as IFN-γ, and apoptosis in the cortical region of the thymus. We show that anti-CD3 Ab induces IL-15 mRNA in spleens of wild-type but not IFN-γ receptor-knock-out (IFN-γR KO) mice. The loss of IL-15...

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Main Authors: Matthys, P, DOOMS, H, ROTTIERS, P, MITERA, T, OVERGERGH, L, LECLERCQ, G, BILLIAU, A, GROOTEN, J
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906542/
https://ncbi.nlm.nih.gov/pubmed/12452826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2002.02013.x
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