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Differential roles of osteopontin/Eta-1 in early and late lpr disease
The cytokine osteopontin (Eta-1) leads to macrophage-dependent polyclonal B-cell activation and is induced early in autoimmune prone mice with the lpr mutation, suggesting a significant pathogenic role for this molecule. Indeed, C57BL/6-Fas(lpr/lpr) mice crossed with osteopontin(−/–) mice display de...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2001
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1906233/ https://ncbi.nlm.nih.gov/pubmed/11737079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01702.x |
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