Complete arrest from pro- to pre-B cells in a case of B cell-negative severe combined immunodeficiency (SCID) without recombinase activating gene (RAG) mutations

The B-cell lineage in a patient with B-cell-negative severe combined immunodeficiency (SCID) was analysed by using antisurrogate light chain (SL) MoAbs. Peripheral CD3(+) T cells and CD19(+) B cells were absent in the patient. The common gamma (γc) chain was expressed normally on the patient's...

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Autors principals: Agematsu, K, Nagumo, H, Hokibara, S, Mori, T, Wada, T, Yachie, A, Kanegane, H, Miyawaki, T, Sugita, K, Karasuyama, H, Komiyama, A
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2001
Matèries:
Immunodeficiency
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906068/
https://ncbi.nlm.nih.gov/pubmed/11472408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01553.x
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