Pentoxifylline inhibits the synthesis and IFN-γ-inducing activity of IL-18

The effect of phosphodiesterase-inhibiting anti-inflammatory drug pentoxifylline (PTX) on LPS-induced IL-18 synthesis and IL-18-mediated IFN-γ-induction were investigated. In a dose-dependent manner PTX inhibited production of IL-18 in LPS-treated cultures of murine spleen cells and bone marrow-deri...

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Hauptverfasser: Samardzic, T, Jankovic, V, Stosic-Grujicic, S, Popadic, D, Trajkovic, V
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2001
Schlagworte:
Immunopharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906051/
https://ncbi.nlm.nih.gov/pubmed/11422205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01546.x
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