Primate TNF Promoters Reveal Markers of Phylogeny and Evolution of Innate Immunity

BACKGROUND: Tumor necrosis factor (TNF) is a critical cytokine in the immune response whose transcriptional activation is controlled by a proximal promoter region that is highly conserved in mammals and, in particular, primates. Specific single nucleotide polymorphisms (SNPs) upstream of the proxima...

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Autori principali: Baena, Andres, Mootnick, Alan R., Falvo, James V., Tsytsykova, Alla V., Ligeiro, Filipa, Diop, Ousmane M., Brieva, Claudia, Gagneux, Pascal, O'Brien, Stephen J., Ryder, Oliver A., Goldfeld, Anne E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905939/
https://ncbi.nlm.nih.gov/pubmed/17637837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000621
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