Pharmacokinetics of [(18)F]Fluoroalkyl Derivatives of Dihydrotetrabenazine (DTBZ) in Rat and Monkey Brain

The specific binding and regional brain pharmacokinetics of new fluorine-18 labeled radioligands for the vesicular monoamine transporter (VMAT2) were examined in the rat and primate brain. In the rat, 9-[(18)F]fluoropropyl-(±)-9-O-desmethyldihydrotetrabenazine ([(18)F]FP-(±)-DTBZ) showed better spec...

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Bibliografiset tiedot
Päätekijät: Kilbourn, Michael R., Hockley, Brian, Lee, Lihsueh, Hou, Catherine, Goswami, Rajesh, Ponde, Datta E., Kung, Mei-Ping, Kung, Hank F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905841/
https://ncbi.nlm.nih.gov/pubmed/17383572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2007.01.007
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