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Pharmacokinetics of [(18)F]Fluoroalkyl Derivatives of Dihydrotetrabenazine (DTBZ) in Rat and Monkey Brain
The specific binding and regional brain pharmacokinetics of new fluorine-18 labeled radioligands for the vesicular monoamine transporter (VMAT2) were examined in the rat and primate brain. In the rat, 9-[(18)F]fluoropropyl-(±)-9-O-desmethyldihydrotetrabenazine ([(18)F]FP-(±)-DTBZ) showed better spec...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1905841/ https://ncbi.nlm.nih.gov/pubmed/17383572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2007.01.007 |
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