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Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)-induced arthritis

The central role of CD4(+) T cells and the balance between T helper (Th) subpopulations in the pathogenesis of autoimmune diseases have been extensively studied. Proteoglycan (aggrecan)-induced arthritis (PGIA) is a murine model for rheumatoid arthritis (RA), which is characterized by a Th1 dominanc...

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Détails bibliographiques
Auteurs principaux: Holló, K, Glant, T T, Garzó, M, Finnegan, A, Mikecz, K, Buzás, E
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2000
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905608/
https://ncbi.nlm.nih.gov/pubmed/10759779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2000.01174.x
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