Antigen-specific B cells present cartilage proteoglycan (aggrecan) to an autoreactive T cell hybridoma derived from a mouse with proteoglycan-induced arthritis.

Cartilage proteoglycan (aggrecan)-induced polyarthritis in BALB/c mice is characterized by chronic inflammation and destruction of joint tissues similar to that observed in human rheumatoid arthritis. The immunization of mice with fetal human proteoglycan (PG) elicits specific antibodies to the immu...

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Bibliografiske detaljer
Main Authors: Brennan, F R, Mikecz, K, Buzás, E I, Ragasa, D, Cs-Szabó, G, Negroiu, G, Glant, T T
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1553246/
https://ncbi.nlm.nih.gov/pubmed/7664487
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