Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis

BALB/c mice immunized with human cartilage proteoglycan (PG) develop arthritis accompanied by the production of autoantibodies to mouse cartilage PG. To determine whether the autoantibody isotype contributes to the onset and severity of arthritis, PG-specific serum IgG1 (Th2, IL-4-cytokine-supportin...

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Bibliografski detalji
Glavni autori: Kaplan, Charles, Valdez, Juan C, Chandrasekaran, Raman, Eibel, Hermann, Mikecz, Katalin, Glant, Tibor T, Finnegan, Alison
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2002
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC64852/
https://ncbi.nlm.nih.gov/pubmed/11879537
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