Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis

BALB/c mice immunized with human cartilage proteoglycan (PG) develop arthritis accompanied by the production of autoantibodies to mouse cartilage PG. To determine whether the autoantibody isotype contributes to the onset and severity of arthritis, PG-specific serum IgG1 (Th2, IL-4-cytokine-supportin...

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Detalhes bibliográficos
Main Authors: Kaplan, Charles, Valdez, Juan C, Chandrasekaran, Raman, Eibel, Hermann, Mikecz, Katalin, Glant, Tibor T, Finnegan, Alison
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC64852/
https://ncbi.nlm.nih.gov/pubmed/11879537
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