Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis

BALB/c mice immunized with human cartilage proteoglycan (PG) develop arthritis accompanied by the production of autoantibodies to mouse cartilage PG. To determine whether the autoantibody isotype contributes to the onset and severity of arthritis, PG-specific serum IgG1 (Th2, IL-4-cytokine-supportin...

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Autori principali: Kaplan, Charles, Valdez, Juan C, Chandrasekaran, Raman, Eibel, Hermann, Mikecz, Katalin, Glant, Tibor T, Finnegan, Alison
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2002
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC64852/
https://ncbi.nlm.nih.gov/pubmed/11879537
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