No association between neutrophil FcγRIIa allelic polymorphism and anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis

ANCA, implicated as having a pathogenic role in systemic vasculitis, can activate tumour necrosis factor-alpha (TNF-α)-primed neutrophils by cross-linking surface-expressed ANCA antigens with neutrophil FcγRIIa receptors to release reactive oxygen species. The FcγRIIa receptor exists as polymorphic...

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Autori principali: TSE, WY, ABADEH, S, MCTIERNAN, A, JEFFERIS, R, SAVAGE, COS, ADU, D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 1999
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905477/
https://ncbi.nlm.nih.gov/pubmed/10403936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1999.00960.x
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