Limitations of the semisynthetic library approach for obtaining human monoclonal autoantibodies to the thyrotropin receptor of Graves' disease

Graves' disease (GD) is characterized by the presence of autoantibodies against the TSH-receptor (TSH-R) which are pathogenic and, upon binding to the receptor, trigger intracellular signal transduction. The autoantibodies are oligoclonal and as they are responsible for disease activity, their...

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Main Authors: Van Der Heijden, J H W, De Bruin, T W A, Glaudemans, K A F M, De Kruif, J, Banga, J P, Logtenberg, T
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 1999
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905415/
https://ncbi.nlm.nih.gov/pubmed/10540180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1999.01042.x
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