Limitations of the semisynthetic library approach for obtaining human monoclonal autoantibodies to the thyrotropin receptor of Graves' disease

Graves' disease (GD) is characterized by the presence of autoantibodies against the TSH-receptor (TSH-R) which are pathogenic and, upon binding to the receptor, trigger intracellular signal transduction. The autoantibodies are oligoclonal and as they are responsible for disease activity, their...

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Bibliographische Detailangaben
Hauptverfasser: Van Der Heijden, J H W, De Bruin, T W A, Glaudemans, K A F M, De Kruif, J, Banga, J P, Logtenberg, T
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 1999
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905415/
https://ncbi.nlm.nih.gov/pubmed/10540180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1999.01042.x
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