Enhanced expression of CTLA-4 (CD152) on CD4(+) T cells in HIV infection

CTLA-4 (CD152) is a surface molecule of activated T cells with sequence homology to CD28. Both molecules bind to the same ligands, B7.1 (CD80) and B7.2 (CD86) but have antagonistic functions. While CD28 is an important costimulator, CTLA-4 has an essential inhibitory function in maintaining the home...

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Bibliographic Details
Main Authors: Steiner, K, Waase, I, Rau, T, Dietrich, M, Fleischer, B, BröKer, B M
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 1999
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905266/
https://ncbi.nlm.nih.gov/pubmed/10193417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1999.00806.x
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