A proportion of proteinase 3 (PR3)-specific anti-neutrophil cytoplasmic antibodies (ANCA) only react with PR3 after cleavage of its N-terminal activation dipeptide

ANCA directed against PR3 are highly specific for Wegener's granulomatosis and microscopic polyangiitis, and have been implicated in the pathogenesis of small vessel vasculitis. Most PR3-ANCA are directed against conformational epitopes on PR3. This study was designed to determine whether the c...

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Detalhes bibliográficos
Main Authors: Sun, J, Fass, D N, Viss, M A, Hummel, A M, Tang, H, Homburger, H A, Specks, U
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1998
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905112/
https://ncbi.nlm.nih.gov/pubmed/9822293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1998.00730.x
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