Glycosylation of proteinase 3 (PR3) is not required for its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener’s granulomatosis

OBJECTIVE: The glycosylation status of autoantigens appears to be crucial for the pathogenesis of some autoimmune diseases, since carbohydrates play a crucial role in the distinction of self from non-self. Proteinase 3 (PR3), the main target antigen for anti-neutrophil cytoplasmic antibodies (ANCA)...

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Main Authors: Finkielman, J.D., Merkel, P.A., Schroeder, D., Hoffman, G.S., Spiera, R., St. Clair, E.W., Davis, J.C., McCune, W.J., Lears, A., Ytterberg, S.R., Hummel, A.M., Viss, M.A., Peikert, T., Stone, J.H., Specks, U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183098/
https://ncbi.nlm.nih.gov/pubmed/19646346
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