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What you should know about PR3-ANCA: Conformational requirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3-ANCA
The neutrophil azurophil granule constituent proteinase 3 (PR3) is the principal antigen for anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis. The conformation of the mature PR3 enzyme results from intracellular post-translational processing. The nascent molecule underg...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2000
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC130016/ https://ncbi.nlm.nih.gov/pubmed/11094439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar99 |
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