Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis

The effect of blocking IL-12, a potent inducer of interferon-gamma (IFN-γ) and promoter of Th1 cell responses, during the induction phase of CIA was investigated. Arthritis was elicited in male DBA/1 mice by immunizing with type II collagen (CII) in Freund's complete adjuvant. Neutralizing anti...

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Detalhes bibliográficos
Main Authors: Malfait, A M, Butler, D M, Presky, D H, Maini, R N, Brennan, F M, Feldmann, M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1998
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904910/
https://ncbi.nlm.nih.gov/pubmed/9486407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1998.00485.x
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