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B cell-deficient mice do not develop type II collagen-induced arthritis (CIA)

To investigate the role of B cells in the development of CIA, a model for rheumatoid arthritis, we investigated susceptibility to CIA in mice lacking B cells due to the deletion of the IgM heavy chain gene (μMT). The μMT deletion was backcrossed into two different CIA-susceptible strains, B10.Q and...

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Autors principals: Svensson, L, Jirholt, J, Holmdahl, R, Jansson, L
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904879/
https://ncbi.nlm.nih.gov/pubmed/9528892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1998.00529.x
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