Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A.

The cellular peptidyl-prolyl isomerase cyclophilin A is incorporated into human immunodeficiency virus type 1 virions via contacts with the proline-rich domain of the Gag polyprotein. Cyclosporine A and nonimmunosuppressive analogs bind with high affinity to cyclophilin A, compete with Gag for bindi...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Braaten, D, Aberham, C, Franke, E K, Yin, L, Phares, W, Luban, J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190472/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8764025/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.8.5170-5176.1996
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