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CD8(+) T cells and not CD4(+) T cells are hyporesponsive to CD28- and CD40L-mediated activation in HIV-infected subjects

T cell dysfunction in HIV-infected subjects could be the consequence of altered sensitivity of CD4(+) or CD8(+) T cells to various costimulatory signals. Therefore, we studied proliferation and cytokine production in highly purified CD8(+) and CD4(+) T cells from HIV-infected and HIV(−) subjects, in...

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Detalhes bibliográficos
Main Authors:	VINGERHOETS, J, KESTENS, L, PENNE, G, DE VUYST, H, VANDENBRUAENE, M, PELGROM, Y, BOSMANS, E, DE BOER, M, KASRAN, A, AZUMA, M, COLEBUNDERS, R, CEUPPENS, J L, VANHAM, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Blackwell Science Inc 1997
Assuntos:	Original Articles
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1904613/ https://ncbi.nlm.nih.gov/pubmed/9067514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1997.d01-964.x
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CD8(+) T cells and not CD4(+) T cells are hyporesponsive to CD28- and CD40L-mediated activation in HIV-infected subjects

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