Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8+ T cells from HIV-infected subjects.

The CD28 receptor on CD4+ and CD8+ T cells interacts with B7 molecules on antigen-presenting cells (APC) to generate essential costimulatory signals. The cytolytic potential of CD8+ T cells could be linked to CD28 expression. Since HIV induces dysfunction of both CD4+ and CD8+ T cells, we evaluated...

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Main Authors: Vingerhoets, J H, Vanham, G L, Kestens, L L, Penne, G G, Colebunders, R L, Vandenbruaene, M J, Goeman, J, Gigase, P L, De Boer, M, Ceuppens, J L
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1534479/
https://ncbi.nlm.nih.gov/pubmed/7539725
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