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Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain

Soluble epoxide hydrolases catalyze the hydrolysis of epoxides in acyclic systems. In man this enzyme is the product of a single copy gene (EPXH-2) present on chromosome 8. The human sEH is of interest due to emerging roles of its endogenous substrates, epoxygenated fatty acids, in inflammation and...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Inceoglu, Bora, Jinks, Steven L., Schmelzer, Kara R., Waite, Troy, Kim, In Hae, Hammock, Bruce D.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904345/
https://ncbi.nlm.nih.gov/pubmed/16962614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2006.07.031
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