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An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations
Mutations in ras and p53 are the most prevalent mutations found in human nonmelanoma skin cancers. Although some p53 mutations cause a loss of function, most result in expression of altered forms of p53, which may exhibit gain-of-function properties. Therefore, understanding the consequences of acqu...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1904325/ https://ncbi.nlm.nih.gov/pubmed/17607363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31721 |
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