Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

We and others have recently shown that loss of the mitochondrial membrane potential (Δψ) precedes apoptosis and chemical-hypoxia-induced necrosis and is prevented by Bcl-2. In this report, we examine the biochemical mechanism used by Bcl-2 to prevent Δψ loss, as determined with mitochondria isolated...

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Detalhes bibliográficos
Main Authors: Shimizu, Shigeomi, Eguchi, Yutaka, Kamiike, Wataru, Funahashi, Yoshimitsu, Mignon, Alexandre, Lacronique, Virginia, Matsuda, Hikaru, Tsujimoto, Yoshihide
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC19042/
https://ncbi.nlm.nih.gov/pubmed/9465036
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