Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux
We and others have recently shown that loss of the mitochondrial membrane potential (Δψ) precedes apoptosis and chemical-hypoxia-induced necrosis and is prevented by Bcl-2. In this report, we examine the biochemical mechanism used by Bcl-2 to prevent Δψ loss, as determined with mitochondria isolated...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19042/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9465036/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.4.1455 |
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